Premier League Betting 21/22: Manchester United vs Liverpool Betting Preview

Written By Alex Blowers on October 21, 2021

This Sunday, Liverpool travel to Old Trafford to face Manchester United for the Premier League‘s biggest fixture.  These two are the most successful clubs in English football, with United ahead on trophies by one with 66. The game is scheduled to kick off at 11:30AM EST and will be shown live on NBCSN.

Both are coming off 3-2 victories in the UEFA Champions League but in very different circumstances.

Liverpool traveled to the Wanda Metropolitano to play Atlético Madrid in a game that will be remembered as a Group Stage classic. Jurgen Klopp‘s side surrendered a 2-0 lead and looked destined to return to England with a point until Mario Hermoso wiped out Diogo Jota to give away a penalty. The world’s current best player Mohamed Salah stepped up to score his 12th goal of the season and secure Liverpool the 3 points.

Manchester United welcomed Atalanta to Old Trafford, and they gave themselves a mountain to climb after ending the first half 2-0 down. As we’ve seen time and time again under Ole Gunnar Solksjaer, United were able to turn it around and win the game 3-2 with goals from Marcus Rashford, Harry Maguire, and Cristiano Ronaldo.


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Premier League Betting: Manchester United vs Liverpool Betting Preview


CompetitionOpponentHome/AwayGoals ForGoals AgainstxG ForxG AgainstxG Difference
Premier LeagueAston VillaHome012.31.2+1.1
UEFA Champions LeagueVillarrealHome121.41.7-0.3
Premier LeagueEvertonHome110.91.1-0.2
Premier LeagueLeicester CityAway241.33.1-1.8
UEFA Champions LeagueAtalantaHome322.91.2+1.7
Total / Average7 / 1.410 / 28.8 / 1.768.3 / 1.66+0.5 / +0.1

Stats taken from FBREF

Premier League Betting: Manchester United vs Liverpool Betting Preview

Out: Raphaël Varane (Groin)
Doubtful: Fred (Unknown), Amad Diallo (Thigh), Anthony Martial (Knock)
Suspended: None
Coach: Ole Gunnar Solksjaer

Fred was subbed off in the 88th minute against Atalanta, and United are yet to reveal what the injury is and how long he is out. If he is fit enough to start, he will play alongside Scott McTominay. These two were Solksjaer’s preferred central midfield duo for the big games last season.

If he isn’t fit, Paul Pogba will take his place, which will be the only change Solksjaer makes to the side that started against Atalanta. David De Gea, Luke Shaw, Aaron Wan-Bissaka, and Bruno Fernandes have cemented their places. Mason Greenwood has been brilliant on the left, and Rashford has got on the scoresheet in their last two games. Solksjaer hasn’t got the stones to bench Cristiano Ronaldo despite Edinson Cavani being the better option for this game.

United’s best defender Raphaël Varane is out for the next few weeks with a groin injury he picked up while away with France. In central defense, Victor Lindelöf will continue to partner Maguire who has been poor since his return from injury. Against Atalanta and Leicester City, the England international made poor positional decisions for crosses that led to goals.

This week, Amad Diallo returned to training after overcoming the groin injury that scuppered his loan move to Feyenoord. Anthony Martial also returned after missing United’s last two games with a knock he picked up on international duty. If both are fit enough for this game, they’ll start on the bench.


CompetitionOpponentHome/AwayGoals ForGoals AgainstxG ForxG AgainstxG Difference
Premier LeagueBrentfordAway332.51.9+0.6
UEFA Champions LeagueFC PortoAway513.70.5+3.2
Premier LeagueManchester CityHome221.01.1-0.1
Premier LeagueWatfordAway503.60.5+3.1
UEFA Champions LeagueAtlético MadridAway321.21.5-0.3
Total / Average18 / 3.68 / 1.612 / 2.45.5 / 1.16.5 / 1.3

Stats taken from FBREF

Premier League Betting: Manchester United vs Liverpool Betting Preview

Out: Harvey Elliot (Ankle), Curtis Jones (Muscle)
Doubtful: Thiago Alcântara (Calf)
Suspended: None
Coach: Jurgen Klopp

I’m confident Fabinho will return to the starting lineup after starting on the bench against Atlético. Klopp surprisingly stuck with the same midfield three of Jordan Henderson, James Milner, and Naby Keïta, who played very well in the 5-0 win over Watford last weekend.

At 35-years-old I doubt Milner’s ability to play three games in eight days. Alex Oxlade-Chamberlain replaced him in the 63rd minute midweek, and I think we could see him start on Sunday. Keïta is also an option, but he was at fault for Atlético’s first letting Thomas Lemar beat him way too easily and was subbed off at halftime.

The front three and back four pick themselves for the big games. Joël Matip has been outstanding, and Joe Gomez will have to wait patiently on the bench for an opportunity to get back into the first eleven. Klopp will introduce Diogo Jota from the bench in the second half.

Harvey Elliott is a long-term absentee, and if Curtis Jones or Thiago Alcantara makes the squad, it will be on the bench.


If you’ve been listening to the High Press Podcast, you will have heard me talk many times about how flawed this Manchester United side is. They’re so unpredictable and rely on individual talent and moments of brilliance to win games rather than playing in a defined way with a clear game plan.

That will get you points against weak and average teams, but it isn’t enough against the very best and well-structured sides. Take last weekend’s 4-2 defeat against Leicester City. Michael Cox of The Athletic did an excellent piece highlighting how Brendan Rodgers‘s side were able to bypass United’s press and pass through their midfield time and time again.

Their opponent Liverpool are one of the best sides in Europe who are yet to taste defeat this season, winning nine and drawing three. Everything points to Klopp’s side getting the 3 points, and I think they could win this comfortably.

My recommendation is to back them on the Moneyline at +130 and put a little change behind them on the Spread. Klopp’s side are available at +380 with a -1.5 goal handicap, and I can easily see them winning this game by two or three goals.

PREMIER LEAGUE BETTING TIPS: 75% of your stake on Liverpool Moneyline +130 | 25% of your stake on Liverpool -1.5 Goals +380


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Alex Blowers

Betting advice for the Premier League, Bundesliga & UEFA Champions League! Twitter - @AlexJBlowers

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