UEFA Champions League Betting 21/22: First Leg Last 16 Lines Week Two

Written By Alex Blowers on February 21, 2022

This week is the second batch of UEFA Champions League First Leg Last 16 matches. Hopefully, these eight teams can deliver the same amount of action, late drama, and upsets we saw in the first four fixtures.

The marquee tie takes place on Wednesday at the Wanda Metropolitano between Atlético Madrid and Manchester United. Elsewhere, misfiring Chelsea faces a Lille OSC side struggling to replicate their form from last season. Juventus travel to Spain to take on Villarreal, and Benfica hosts Ajax, the competition’s dark horse.

If you’re unsure about what markets to choose for these games, you can read on to see my picks and check out our UEFA Champions League Betting Guide.

You can always hit me up on Twitter @AlexJBlowers for advice, your picks, and thoughts on what’s happening in the world of soccer. If you’re unsure about what markets to bet on this Matchday, you can read on to see my analysis and check out our Premier League Betting Guide.

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Let’s take a look at the 2021-22 UEFA Champions League Last 16 First Leg Betting Lines.


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UEFA Champions League Competition Details


UEFA Champions League Betting: First Leg Last 16 Lines Week Two

*Odds Taken from DraftKings Saturday, February 19th, 5:30 PM EST


  • With home advantage, I think Chelsea beats Lille OSC. At -300, you’re going to have to delve into the Parlay or Same Game Parlay market to find value. Chelsea To Win and Under 3.5 Goals at -120 might be the way to go. The last time one of their matches finished with four or more goals was eight games ago.
  • Juventus’s Moneyline at +190 is very tempting, with Gerard Moreno a huge doubt for Villarreal. Their January signing Dušan Vlahović is available at +200 to score anytime.
  • We’ll likely see goals in Atlético Madrid vs. Manchester United the way they’ve been playing recently. Both Teams To Score YES and Over 2.5 Goals is available at +140.
  • I would play it safe and take Ajax’s Moneyline at -115 for their match against Benfica.


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Alex Blowers

Betting advice for the Premier League, Bundesliga & UEFA Champions League! Alex also contributes to NBC Sports Edge and TheLines. You can follow him on Twitter @AlexJBlowers

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